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Increased risk of drug-related mortality from concomitant use with opioids. Therapy for 4 months. Discontinue if paradoxical reactions occur. Primary depressive disorder or psychosis: not recommended. Suicidal tendencies (monitor). Renal or hepatic impairment. Compromised respiratory function. Seizure disorder. Reevaluate periodically. Monitor blood counts, liver function with long-term use. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Change dose gradually. Drug or alcohol abuse. Elderly. Debilitated. Pregnancy (during the 1st trimester), nursing mothers: not recommended.

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