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Overdose Symptoms: European post-marketing reports on zolpidem overdose report a violation of consciousness (from drowsiness to mild coma). Fixed one case of cardiovascular and respiratory disorders. There was a complete recovery after taking doses of zolpidem tartrate to 400 mg (40 times greater than MPDH).Cases of overdose caused by the simultaneous administration of many drugs, depressing the central nervous system, including zolpidem, led to more severe consequences, up to lethal outcomes.Treatment: induction of vomiting or immediate gastric lavage (depending on the condition), the purpose of activated charcoal. The monitoring of vital functions (breathing, pulse, blood pressure, etc.) is shown, if necessary, symptomatic and supportive therapy. It should be abandoned the use of any sedatives (even with pronounced stimulation). Hemodialysis is ineffective. A specific antidote is a benzodiazepine receptor antagonist flumazenil.
From the nervous system: often - drowsiness, a feeling of intoxication, headache, dizziness, increased insomnia, anterograde amnesia (the effects of amnesia can be associated with behavioral reactions), the risk of developing which increases in proportion to the dose, hallucinations, agitation, nightmares; infrequently - confusion, irritability; frequency is unknown - impairment of consciousness, dysphoria, aggressiveness, visual and auditory hallucinations, increased excitability, behavioral reactions, somnambulism, drug dependence (can develop even when therapeutic doses are used), withdrawal of drug - withdrawal syndrome or ricochet insomnia, decreased libido, gait disturbance , ataxia, falls (mainly in elderly patients), drug addiction (reduction of sedative and hypnotic effects when applied for several weeks). Most side effects from the psyche are paradoxical reactions.
From the digestive system: often - diarrhea, nausea, vomiting, abdominal pain; frequency unknown - increased activity of hepatic enzymes.
From the musculoskeletal system: the frequency is unknown - muscle weakness.
On the part of the skin: the frequency is unknown - rash, itching, urticaria, increased sweating.
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As soon as you understand that you have a problem with Ambien abuse, contact your healthcare provider. A doctor will help you develop the scheme of gradual dose reduction that will allow you to stop taking this medication with a minimum number of withdrawal symptoms. In severe cases, Ambien withdrawal can be reduced by taking Valium. Again, it should all go under the doctor's control. Cognitive-behavioral therapy can also be useful for people on Ambien rehab.
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