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From the nervous system: often - drowsiness, a feeling of intoxication, headache, dizziness, increased insomnia, anterograde amnesia (the effects of amnesia can be associated with behavioral reactions), the risk of developing which increases in proportion to the dose, hallucinations, agitation, nightmares; infrequently - confusion, irritability; frequency is unknown - impairment of consciousness, dysphoria, aggressiveness, visual and auditory hallucinations, increased excitability, behavioral reactions, somnambulism, drug dependence (can develop even when therapeutic doses are used), withdrawal of drug - withdrawal syndrome or ricochet insomnia, decreased libido, gait disturbance , ataxia, falls (mainly in elderly patients), drug addiction (reduction of sedative and hypnotic effects when applied for several weeks). Most side effects from the psyche are paradoxical reactions.

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Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.

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Ambien (Zolpidem) is a prescription medication used for short term treatment of insomnia. It belongs to a group of drugs called sedative-hypnotics that work by depressing the central nervous system and slowing down brain activity? While Ambien is generally considered safer than certain other sedatives, it can still be misused. Long-term use may lead to tolerance, dependence, and withdrawal.
When used as prescribed, the traditional form of the drug is taken at bedtime to help users fall asleep. The extended-release version hit the market in 2005 with two layers - the first to put you to sleep and the second, internal layer helped to keep you that way. According to Forbes Magazine, US physicians doled out 40 million prescriptions for the sedative hypnotic drug in 2011.


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